This study investigated the mental health literacy regarding adolescent depression among a sample of 12th grade males in the U.S. Mental health literacy was measured by a vignette-based instrument that offered five fictitious case scenarios followed by a series of questions related to symptoms, level of concern, stimated time of recovery, and recommended sources of help. Participants demonstrated a moderate ability to detect depression and predict recovery time, and primary help-seeking recommendations ncluded friends, family, and counselors. Implications related to counseling and prevention programs are discussed.