This article presents a number of concepts, strategies, methodologies, and issues linked with both conducting indigenous,cultural, and cross-cultural research and the counseling of diverse populations in the Asia-Pacific Rim. Important termsassociated with these topics are defined (e.g., diversity, culture, U.S. centric and ethnocentric biases, construct, method, item,and linguistic biases, equivalence, cultural psychology, indigenous psychology, multicultural counseling, multiculturalpsychology, cross-cultural counseling, cross-cultural psychology, cross-national counseling, cross-cultural validity, andtranslation and back-translation procedures) and discussed in the context of performing culturally appropriate, valid, andeffective counseling research and practice. Further, the cross-cultural MAKS (Motivation, Awareness, Knowledge, andSkills) paradigm is introduced as a viable, heuristic, and parsimonious approach for engaging in such professional activities.Finally, challenges and opportunities of conducting indigenous, cultural, and cross-cultural research and counseling arehighlighted.